Submission of New Applications & 3-Year Renewals of IACUC Protocols


Go to RMS Website

Additional Information & Tips

  1. Log into RMS
    • New applications:

    • 3-year Renewal = If your AUP has info in the protocol tabs you wish to copy over...
      • Right-click or Ctrl+click (Mac) the File (not the Document),
      • Select the option to Duplicate File, then
      • Update protocol tabs to reflect experiments to be performed in the next 3 years.
      • NOTE:  "Duplicate" feature is temporarily disabled.  Please follow the instructions for creating a new protocol.
  2. Email to let us know about your submission.

TIP:  You may refer to the old Word Document versions of your IACUC protocol and copy/paste relevant information into the appropriate RMS sections. 
- Request for copies by emailing us at

  • See the RMS User Guide for guidance on how to use RMS.

    Contact the RMS Help Desk if you need assistance:

  • See the Protocol Writing Tips & Guidance page for tips and recommendations on how to answer the questions and improve your chances of obtaining IACUC approval.
  • IMPORTANT:  Principal Investigator must complete required CITI training, or this may delay application processing. 
  • It is strongly recommended to submit your submission as early as possible. Submissions must be received by the deadline date and time to be considered as an item on the full committee meeting agenda

    (See the Committee Calendar for submission deadlines and meeting dates)

    NOTE:  Submitting by the deadline date does NOT guarantee making it onto the meeting agenda! Agenda capacity is determined on a first-come first-served basis, dependent on the number of submissions already received and the number of scientific reviewers available.

  • During the pre-review process, researcher responses need to be entered in RMS.

    (See Guidance for Responding to Review webpage for more info)
  • For guidance about hazards, please contact EH&S at (949) 824-2041

   Important Reminders:

  • For 3-year renewals, the renewal application must be reviewed and approved before the current protocol cycle expires to avoid a lapse in approval. If the current protocol expires before the renewal is approved, all live animal work must cease and may not resume until approval from the IACUC has been obtained for the new cycle. 

    Any remaining animals housed under the expired protocol will be transferred to the ULAR Holding Protocol.  Animals on the holding protocol are off-limits to investigators and no experimental manipulations or observations are allowed.  Refer to the Holding Protocol Policy for more information.
  • All laboratory personnel with live-animal contact must complete the Laboratory Animal Occupational Health Program (LAOHP) Questionnaire (this needs to be updated annually).  Refer to the LAOHP for more information. For questions regarding the LAOHP, please contact EH&S at (949) 824-3757.

  • Other additional regulatory committee reviews may be required for your study, if you use any of the following:
    • Hazardous Agents (e.g., infectious agents, human/primate materials, recombinant DNA, chemical, etc.) may require IBC review – Contact or (949) 824-8024
    • Human Stem Cells (e.g., embryonic, induced adult hSCs, etc.) may require hSCRO review – Contact
    • Radioactive agents or instruments (e.g., iodinated proteins, irradiator, X-rays, etc.) may require RSC review – Contact RSC at (949) 824-6098 or (949) 824-4557
    • Human cells (e.g., patient cancer cells, blood, tissues, etc.) may require IRB review – Contact

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