UC Campuses MOU Instructions


Note: The Reviewing Principal Investigator (PI) must initially create any Reliance Request and will invite all Relying PI’s as part of their initial request. After receiving the invitation from the Reviewing PI, the Relying PI can then log into the Registry and acknowledge their participation.

All first-time users must register with the UC IRB Reliance Registry before they create a new reliance request.

  • If you are the Reviewing PI, go to
  • For first-time registration, click “Register” and complete the “User Registration” form. A temporary password will be sent to your email address. Use the temporary password to log in to the Registry and create a new password. Registration is now complete.

Creating a New Reliance Request

  • If you are the Reviewing PI, click the Create Request tab and disclose if your study involves Veteran Administration. If the study does involve the Veteran Administration the Reliance Process cannot be used and a new study should be submitted online at the following website:  Otherwise, complete the information regarding your role in the study and the other required fields marked by an asterisk. Make sure to save your entries if you need to log out at any time.
  • Identify your Relying PIs. The UC IRB Reliance Registry will notify Relying PIs via email to register and confirm their involvement in the study. Email addresses must be entered accurately as there is no bounce-back function in the system.
  • Once all Relying PIs have signed up for the study via the UC IRB Reliance Registry, the Reviewing PI will be able to sign a reliance request form, convert it to a PDF and submit it with their protocol application to their campus IRB for review.
  • Upon approval of the study, the Reviewing IRB will add the approval/expiration date, approved protocol, approval letter and any applicable consent forms to the study’s UC IRB Reliance Registry record and an automated email notice will be sent to all PIs and the Relying IRB.
  • The Relying IRB will review the documents and accept or deny the reliance via the UC IRB Reliance Registry. UCI will ask that our Relying PIs complete the Administrative Registration Form for Research Approved by Another IRB. Student investigators will need to have their faculty sponsor sign as well. If accepted, the Relying IRB will upload a Reliance Letter, creating an Active Reliance. All PIs and the Reviewing IRB will be notified of this decision via automated email.

Submitting Renewals and Amendments

Reviewing PIs should submit Continuing Review applications of their studies to their campus IRB, per usual. Upon approval, the Reviewing IRB will update the study’s expiration date in the UC IRB Reliance Registry. No Relying PI can continue work on the study if the Reviewing Campus does not submit a renewal on time.

Amendments must be submitted to the Reviewing IRB who will update any changes to the study in the UC IRB Reliance Registry. The Relying PI is also responsible for informing the Reviewing PI of any necessary amendments.

Reporting Adverse/ Unanticipated Events

Reports of adverse and/or unanticipated events that occur at UCI or at any study site where UCI is the Reviewing IRB must be submitted via the online AE/UP website.

Contact Information

For further assistance, please contact Jessica Sheldon at or Karen Allen at

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